Mazdutide (IBI362) GLP-1/Glucagon Agonist – 10mg

Description

Mazdutide (IBI362)

Mazdutide (designated as IBI362) is a high-potency synthetic oxyntomodulin-like peptide that functions as a dual agonist for both the Glucagon-like peptide-1 receptor (GLP-1R) and the Glucagon receptor (GCGR). In the landscape of cutting-edge metabolic pharmacology, Mazdutide is distinguished by its synergistic “dual-pathway” approach. While the GLP-1R activation focuses on glucose-dependent insulin secretion and appetite suppression, the integration of the Glucagon receptor (GCGR) stimulation enhances energy expenditure and promotes hepatic fatty acid oxidation. This complex provides researchers with an unparalleled experimental tool to investigate non-linear weight loss mechanisms, improvements in insulin sensitivity, and the mitigation of metabolic dysfunction-associated steatotic liver disease (MASLD).

Our Mazdutide is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing advanced Solid-Phase Peptide Synthesis (SPPS) and high-resolution multi-stage HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated sequences and synthesis by-products, guaranteeing the structural fidelity and batch-to-batch consistency required for high-stakes research into energy homeostasis.

Research Applications & Mechanisms

Dual-Receptor Synergy (GLP-1R/GCGR)

Investigating the potentiation of metabolic signaling when incretin pathways are combined with glucagon-mediated energy expenditure.

Enhanced Thermogenesis & Lipolysis

Researching the molecular mechanisms through which Mazdutide stimulates white adipose tissue browning and increases basal metabolic rate.

Glycemic Control & Hepatic Health

Studying the peptide’s influence on glucose homeostasis and its role in investigating the reduction of intrahepatic lipid content in specialized liver research models.

Satiety & Neuro-Endocrine Signaling

Exploring the impact of dual-agonist signaling on the hypothalamic appetite centers and its long-term effects on energy intake regulation.

Technical Specifications

Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the Mazdutide powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and protects the complex dual-agonist sequence from oxidative degradation during storage.

Structural Integrity & Potency

Every batch undergoes strict Mass Spectrometry (MS) to confirm the specific molecular weight and HPLC to verify purity levels exceed research requirements, ensuring maximal receptor binding affinity.

Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Mazdutide cake is at the base.

• Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 14-21 days for optimal results.

Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Mazdutide peptide.

• Verified Quality: A batch-specific Certificate of Analysis (COA) and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

⚠️ Research Disclaimer

Product-Specific Safety Notice: This Mazdutide (IBI362) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

Scientific Resources & References

• National Center for Biotechnology Information (NCBI): Mazdutide (IBI362) Research & Dual-Agonist Mechanism

• Mazdutide 9 mg in Chinese adults with a body mass index ≥30 kg/m2 but without diabetes: A phase 2 randomized controlled trial

🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [Metabolic Study]: The Dual Agonist Frontier: Exploring Mazdutide in Modern Obesity Research