Description

Thymosin alpha 1

Thymosin Alpha 1 (Tα1) is a chemically synthesized, 28-amino acid polypeptide that precisely mimics the naturally occurring hormone secreted by the thymus gland. In the field of advanced biochemical research, Tα1 is a critical focus for its multifaceted role as a potent immunomodulator. It is primarily utilized in laboratory settings to investigate the complex activation and differentiation pathways of T-lymphocytes. By interacting with various Toll-like receptors, Thymosin Alpha 1 provides researchers with a robust experimental instrument to study the host’s innate and adaptive defense mechanisms against viral replication and cellular senescence.

Our Thymosin Alpha 1 is produced within an ISO 9001:2015 certified and GMP-grade manufacturing environment. We employ advanced solid-phase peptide synthesis (SPPS) and rigorous multi-step HPLC purification to achieve an ultra-high chemical purity of ≥99%. This extreme precision ensures that your research into cytokine regulation and immune signaling remains untainted by synthetic by-products or bio-contaminants, allowing for high-fidelity, reproducible data collection in sensitive in-vitro and in-vivo models.

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Research Applications & Mechanisms

• T-Lymphocyte Maturation: Investigating the molecular triggers through which Tα1 promotes the maturation of CD3+, CD4+, and CD8+ cells.

• Antiviral Signaling Research: Studying the inhibitory effects of the Tα1 sequence on viral entry and intracellular replication within host cells.

• Cytokine Homeostasis: Researching the peptide’s ability to balance pro-inflammatory and anti-inflammatory cytokines, specifically involving IL-2 and IFN-γ cascades.

• Immunosenescence Models: Exploring the role of thymic peptides in restoring immune function within aging biological models.

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Technical Specifications

Parameter	Laboratory Standard
Manufacturing Standard	ISO 9001:2015 Certified Facility
Production Quality	GMP-Level Compliance
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	3108.3 Da
Sequence Verification	Verified via Mass Spectrometry (MS)
Solubility	Highly Soluble in Water / Bacteriostatic Water

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Key Features & Quality Assurance

• Pharmaceutical-Grade Lyophilization: Our specialized freeze-drying technology ensures the surface of the Thymosin Alpha 1 powder is perfectly smooth, flat, and delicate. This uniform cake structure prevents moisture absorption and maintains the long-term structural integrity of the peptide chain.

• Unrivaled Batch Consistency: Rigorous internal audits ensure that every vial of Tα1 meets the exact same molecular profile, ensuring the reliability of longitudinal research data.

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Reconstitution Guide (Important)

• Preparation: Allow the vial to reach room temperature. Centrifuge the vial for 30-60 seconds to ensure the Tα1 cake is positioned at the bottom.

• Solvent: Reconstitute with Sterile Water or 0.9% Normal Saline.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl the vial softly until the solution is completely clear and transparent.

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Storage & Handling

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store reconstituted Tα1 solution at 2–8°C and utilize within 10-14 days for optimal results.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to protect the Thymosin Alpha 1 molecular structure.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This Thymosin Alpha 1 (Tα1) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals using appropriate safety protocols.

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Scientific Resources & References

• National Center for Biotechnology Information (NCBI): Compound Summary – Thymosin Alpha-1 (CID: 16133750)

• Chemical Abstracts Service (CAS): Registry Record – Thymosin Alpha-1 (CAS RN: 62304-98-7)
• PubMed – NIH: Research literature on Thymosin Alpha-1 immune modulation and therapeutic applications

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🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [Immune Study]: The Role of Thymosin Alpha 1 in Modern Viral Defense Models