Description

VIP (Vasoactive Intestinal Peptide)

Our VIP is produced in an ISO 9001:2015 certified facility using advanced Solid-Phase Peptide Synthesis (SPPS) technology. We ensure an ultra-high chemical purity of ≥98%, rigorously validated through High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). This stringent quality control process guarantees a product free from trifluoroacetic acid (TFA) residues and truncated peptide sequences, ensuring the molecular integrity and reproducible biological activity essential for high-fidelity immunological research and therapeutic development assays.

---

Research Applications & Mechanisms

Neuro-Immune Axis Modulation

Investigating the complex signaling between the central nervous system and the immune system. Research focuses on VIP’s ability to act as a potent anti-inflammatory mediator by inhibiting the NF-κB signaling pathway and shifting the cytokine profile from pro-inflammatory to anti-inflammatory (Th1 to Th2 balance).

Vasodynamic Stability & Microcirculation

Studying the peptide’s role in promoting potent vasodilation through the activation of the AC-cAMP (adenylate cyclase-cyclic adenosine monophosphate) pathway. Researchers utilize VIP to explore the optimization of blood flow and the enhancement of nutrient delivery within compromised microvascular environments.

Cellular Cytoprotection & Homeostasis

Exploring the mechanisms through which VIP mitigates oxidative stress-induced apoptosis. Research models focus on its capacity to preserve cellular integrity, stabilize biological barriers, and promote tissue survival under conditions of metabolic or environmental stress.

G-Protein Coupled Receptor (GPCR) Signaling

Investigating the high-affinity interactions between VIP and the VPAC1/VPAC2 receptors. This involves studying the downstream effects of secondary messenger cascades on gene expression, protein synthesis, and the long-term normalization of systemic cellular defense mechanisms.

Technical Specifications

Key Features & Quality Assurance

• Pharmaceutical-Grade Lyophilization: Our proprietary vacuum-sealing process results in a perfectly smooth, flat, and delicate lyophilized cake. This professional structure ensures rapid reconstitution and maximum molecular stability.

• ISO 9001 Quality Management: Every production cycle is governed by strict international standards to guarantee batch-to-batch consistency for reproducible research.

• GMP Compliance: Manufactured in a certified sterile environment to eliminate cross-contamination and ensure the highest chemical identity.

Reconstitution Guide (Important)

To preserve the peptide’s biological activity, follow these protocols:

• Preparation: Allow the vial to reach room temperature. Centrifuge at 30-60 seconds to ensure the cake is positioned at the bottom.

• Solvent Selection: Reconstitute with Sterile Water or Bacteriostatic Water. For long-term stock solutions, a weak acid (e.g., 1% acetic acid) may improve solubility.

• Technique: Gently roll the diluent down the side of the vial. DO NOT SHAKE; swirl gently until the solution is clear.

Storage & Handling

• Long-term: Store at -20°C (Stable for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store reconstituted solution at 2–8°C and utilize within 10-14 days.

Shipping & Documentation

• Global Logistics: Discreet, temperature-controlled packaging.

• Verified Quality: Batch-specific COA (Certificate of Analysis) and HPLC/MS reports are provided with every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

⚠️ Research Disclaimer

For Laboratory Research and Analytical Purposes Only. VIP is NOT a drug, food, or cosmetic and is strictly not intended for human or veterinary consumption.