Description

ACE-031 (ACVR2B-Fc)

ACE-031 (scientifically identified as ACVR2B-Fc) is a high-purity synthetic fusion protein consisting of the extracellular domain of the activin receptor type IIB linked to the Fc portion of human IgG1. In the landscape of advanced musculoskeletal research and regenerative medicine, ACE-031 is recognized as a potent decoy receptor. Its primary mechanism of action involves binding to and neutralizing TGF-beta family ligands—specifically Myostatin (GDF-8) and Activin A. By sequestering these negative regulators of muscle mass, ACE-031 prevents them from signaling through cell surface receptors, thereby promoting significant muscle hypertrophy and increased physical strength. It provides researchers with a high-precision experimental model to investigate the reversal of muscle wasting, the molecular pathways of neuromuscular diseases, and the limits of structural tissue regeneration.

Our ACE-031 is synthesized in an ISO 9001:2015 certified environment utilizing recombinant DNA technology and advanced protein purification protocols. We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the protein is free from endotoxins and residual host cell proteins, guaranteeing the consistency and structural fidelity required for sensitive physiological assays and longitudinal strength research.

---

Research Applications & Mechanisms

Inhibition of Myostatin Signaling

Investigating the systemic sequestration of GDF-8 to study the peptide’s role in promoting the rapid expansion of skeletal muscle fibers (hypertrophy).

Neuromuscular Disease Models

Researching the influence of ActRIIB-Fc on preventing muscle atrophy in experimental models of muscular dystrophy and amyotrophic lateral sclerosis (ALS).

Bone Density & Metabolic Homeostasis

Studying the mechanisms through which Myostatin inhibition impacts systemic bone mineral density and Investigating its role in glucose and lipid metabolism.

Satellite Cell Activation & Repair

Exploring the impact of ACE-031 on the proliferation of myogenic progenitor cells to research the optimization of tissue repair after severe injury.

---

Technical Specifications

Parameter	Laboratory Standard
Compound	ACE-031 (ACVR2B-Fc)
Type	Soluble Fusion Protein / Myostatin Inhibitor
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	~110 kDa (Dimer)
Concentration	Available in 1mg vials
Solubility	Highly Soluble in Water (Aqueous) / PBS
Batch Control	MS & HPLC Analysis Verified

---

Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the ACE-031 powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the fusion protein during long-term storage.

Targeted Decoy Selectivity

Every batch is rigorously tested to ensure maximal binding affinity for Myostatin and Activin, ensuring reproducible results in complex musculoskeletal signaling research.

---

Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the ACE-031 cake is at the base.

• Solvent: Reconstitute with Sterile Water or PBS.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 7-10 days for optimal results.

---

Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the ACE-031 protein.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

---

⚠️ Research Disclaimer

Product-Specific Safety Notice: This ACE-031 is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

---

Scientific Resources & References

• National Center for Biotechnology Information (NCBI): ActRIIB Decoy Receptors and Muscle Growth

• ScienceDirect (Elsevier): P3.18 A Phase 1 multiple ascending dose study to assess the pharmacodynamic effects of ACE-031, an inhibitor of negative muscle regulators, in healthy volunteers

---

🔍 Deep Dive Research

• [Technical Guide]: Handling Large Fusion Proteins: Tips for Research Potency

• [Musculoskeletal Study]: Breaking the Limits: The Science of Myostatin Inhibition via ACE-031