Description

Adipotide (FTPP)

Adipotide (scientifically identified as FTPP or Proapoptotic Peptide) is a synthetic peptidomimetic designed for high-precision metabolic and obesity research. In the landscape of advanced endocrinology, Adipotide is distinguished by its unique, targeted mechanism: it specifically binds to receptors (ANXA2 and prohibitin) located on the endothelial cells of the blood vessels supplying white adipose tissue (WAT). Once bound, the peptide triggers a programmed cell death (apoptosis) cascade, effectively cutting off the blood supply to fat cells. This process, known as targeted vasculature disruption, leads to a subsequent rapid reduction in fat mass and improvement in insulin sensitivity without affecting the central nervous system. It provides researchers with a powerful experimental tool to investigate the rapid reversal of obesity, the dynamics of adipose tissue remodeling, and the molecular pathways of systemic metabolic homeostasis.

Our Adipotide (FTPP) is synthesized in an ISO 9001:2015 certified environment utilizing advanced Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from truncated sequences and residual chemical reagents, guaranteeing the consistency and structural fidelity required for complex metabolic assays and longitudinal adipose research.

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Research Applications & Mechanisms

Targeted Adipose Vasculature Apoptosis

Investigating the mechanism of inducing apoptosis in the blood vessels of white fat to study the subsequent rapid reduction in adipose tissue mass.

Metabolic Homeostasis & Insulin Sensitivity

Researching the influence of Adipotide on systemic glucose regulation and investigating the potential reversal of insulin resistance in experimental models.

Non-CNS Appetite Regulation

Studying the physiological pathways of weight loss that bypass the brain’s appetite centers, providing an alternative to traditional stimulant-based research.

Adipose Remodeling & Organ Health

Exploring the impact of Adipotide on reducing ectopic fat accumulation in the liver and muscle tissues within diverse research designs.

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Technical Specifications

Parameter	Laboratory Standard
Compound	Adipotide (FTPP)
Sequence	CKGGRAKDC-GG-(KLAKLAK)2
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	2555.2 Da
Concentrations	Available in 2mg, 5mg, 10mg vials
Solubility	Highly Soluble in Water (Aqueous) / PBS
Batch Control	MS & HPLC Analysis Verified

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Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the Adipotide powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the complex sequence during storage.

Targeted Binding Affinity Verification

Every batch is verified through high-resolution analysis to ensure the structural integrity of both the homing domain and the pro-apoptotic domain, ensuring reproducible results in targeted tissue research.

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Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Adipotide cake is at the base.

• Solvent: Reconstitute with Sterile Water or PBS.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 7-10 days for optimal results.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Adipotide peptide.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This Adipotide (FTPP) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

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Scientific Resources & References

• National Center for Biotechnology Information (NCBI): Proapoptotic Peptides and Adipose Vasculature Research

• ScienceDirect (Elsevier): Peer-reviewed Research on Adipotide and Metabolic Remodeling

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🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [Metabolic Study]: Starving the Fat: The Science of Targeted Vasculature Disruption via Adipotide