Description

5-AMINO-1MQ (NNMT Inhibitor)

5-AMINO-1MQ (5-Amino-1-methylquinolinium) is a high-purity synthetic small molecule that functions as a potent and selective inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT). In the landscape of advanced metabolic research and anti-aging science, 5-AMINO-1MQ is distinguished by its ability to modulate the cellular methyl-donor balance. NNMT is primarily expressed in adipose and liver tissues, where it plays a critical role in energy metabolism by consuming methyl groups and nicotinamide. By inhibiting NNMT, 5-AMINO-1MQ triggers a systemic increase in intracellular NAD+ levels and activates the SIRT1 (Sirtuin 1) longevity pathway. It provides researchers with a high-precision experimental tool to investigate the reversal of metabolic dysfunction, the enhancement of mitochondrial biogenesis, and the promotion of muscle fiber regeneration in complex aging and obesity research models.

Our 5-AMINO-1MQ is synthesized in an ISO 9001:2015 certified environment utilizing advanced organic synthesis and high-resolution purification techniques. We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the compound is free from heavy metals and residual synthesis reagents, guaranteeing the consistency and structural fidelity required for high-stakes metabolic signaling and muscle physiology assays.

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Research Applications & Mechanisms

NNMT Enzyme Inhibition & NAD+ Boosting

Investigating the systemic upregulation of NAD+ levels by blocking the primary degradation pathway controlled by the NNMT enzyme.

Activation of SIRT1 & Mitochondrial Flux

Researching the mechanisms through which 5-AMINO-1MQ promotes the formation of new mitochondria and investigating enhanced energy expenditure in experimental models.

Adipose Tissue Remodeling & Lipolysis

Studying the conversion of white adipose tissue and the subsequent reduction of fat cell volume in metabolic research designs.

Muscle Regeneration & Myogenic Signaling

Exploring the impact of NNMT inhibition on the activation of satellite cells to research the optimization of muscle repair and strength in aging models.

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Technical Specifications

Parameter	Laboratory Standard
Compound	5-AMINO-1MQ (5-Amino-1-methylquinolinium)
Mechanism	Selective NNMT Inhibitor
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	159.21 g/mol
Concentrations	Available in 5mg, 10mg, 50mg vials
Solubility	Highly Soluble in DMSO / Sterile Water
Batch Control	MS & HPLC Analysis Verified

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Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization Stability

Our proprietary vacuum-sealing process ensures the 5-AMINO-1MQ powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the compound during long-term storage.

High-Precision Small Molecule Verification

Every batch undergoes strict HPLC analysis to confirm a minimum purity of 99%, ensuring that metabolic assays are free from artifacts caused by impurities or unintended enzyme interactions.

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Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the 5-AMINO-1MQ cake is at the base.

• Solvent: Reconstitute with DMSO (for maximum stability) or Sterile Water.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 7-10 days for optimal research results.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the 5-AMINO-1MQ molecule.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This 5-AMINO-1MQ is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

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Scientific Resources & References

• National Center for Biotechnology Information (NCBI): Compound Summary – 5-Amino-1MQ (NNMT inhibitor research compound)

• PubMed – NIH: Research on NNMT inhibition and 5-Amino-1MQ metabolic regulation studies

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🔍 Deep Dive Research

• [Technical Guide]: Reconstitution Best Practices for Small Molecule Metabolic Inhibitors

• [The NAD+ Connection]: Why NNMT Inhibition via 5-AMINO-1MQ is the Future of Anti-Aging Science