Description

AICAR (Acadesine)

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide), also known as Acadesine, is a high-purity synthetic cell-permeable nucleoside. In the landscape of advanced metabolic research and exercise physiology, AICAR is distinguished by its unique ability to function as an AMPK (AMP-activated protein kinase) agonist. By mimicking the intracellular signaling of adenosine monophosphate (AMP), AICAR trick cells into a state of perceived “energy deprivation.” This triggers a systemic metabolic shift, prioritizing catabolic pathways such as fatty acid oxidation and glucose uptake while inhibiting energy-consuming anabolic processes. It provides researchers with a high-precision experimental model to investigate mitochondrial biogenesis, metabolic syndrome, and the molecular pathways of cellular endurance and insulin sensitivity.

Our AICAR is synthesized in an ISO 9001:2015 certified environment utilizing high-resolution chromatography and purification techniques. We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the compound is free from heavy metals and residual organic solvents, guaranteeing the consistency and structural fidelity required for high-stakes metabolic signaling and cardiovascular research.

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Research Applications & Mechanisms

AMPK Pathway Activation

Investigating the systemic upregulation of AMPK to study its role in regulating cellular energy balance and protein kinase cascades.

Mitochondrial Biogenesis & Endurance

Researching the mechanisms through which AICAR promotes the formation of new mitochondria and investigating enhanced muscular performance in experimental models.

Glucose Uptake & Insulin Sensitivity

Studying the non-insulin-dependent pathway of glucose transport into skeletal muscle cells and its role in investigating metabolic dysfunction.

Lipid Oxidation & Adipocyte Signaling

Exploring the impact of AICAR on fatty acid mobilization and the subsequent reduction of lipid accumulation in metabolic research designs.

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Technical Specifications

Parameter	Laboratory Standard
Compound	AICAR (Acadesine)
Chemical Name	5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	258.23 g/mol
Concentrations	Available in 50mg / 100mg vials
Solubility	Highly Soluble in DMSO / Water (Aqueous)
Batch Control	MS & HPLC Analysis Verified

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Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the AICAR powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the compound during long-term storage.

High-Precision Purity Verification

Every batch undergoes strict HPLC analysis to confirm a minimum purity of 99%, ensuring that metabolic assays are free from artifacts caused by impurities or degradation products.

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Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the AICAR cake is at the base.

• Solvent: Reconstitute with DMSO (for maximum stability) or Sterile Water.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 7-10 days for optimal results.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the AICAR compound.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This AICAR (Acadesine) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

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Scientific Resources & References

• National Center for Biotechnology Information (NCBI): AICAR Compound Summary & AMPK Research

• ScienceDirect (Elsevier): Peer-reviewed Research on AICAR and Exercise Mimicry

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🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [Metabolic Study]: The Exercise Pill: Exploring AMPK Activation via AICAR in Modern Science