Description
HMG（Human Menopausal Gonadotropin）
HMG (Human Menopausal Gonadotropin) is a highly purified preparation of gonadotropins extracted from the urine of postmenopausal women or synthesized to mimic the specific biological activity of endogenous hormones. In the landscape of advanced endocrinology and reproductive biology, HMG is uniquely distinguished by its dual-action profile, containing a balanced ratio of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH)—typically standardized at a 1:1 ratio. This synergistic combination provides researchers with a robust experimental model to investigate the regulation of the Hypothalamic-Pituitary-Gonadal (HPG) axis, the induction of steroidogenesis, and the complex molecular signaling involved in both oogenesis and spermatogenesis.
Our HMG is processed in an ISO 9001:2015 certified environment utilizing advanced chromatographic purification techniques. Each vial is standardized to deliver precisely 75iu of biological activity. This rigorous production standard ensures that the complex is free from non-specific proteins and pyrogens, guaranteeing the consistency and potency required for high-fidelity research into hormonal feedback mechanisms and germ cell development.
Research Applications & Mechanisms
Synergistic FSH & LH Signaling
Investigating the dual-pathway activation of G protein-coupled receptors (GPCRs) to study the coordinated stimulation of somatic and germ cells in the gonads.
Folliculogenesis & Ovarian Dynamics
Researching the roles of HMG in investigating the recruitment, maturation, and selection of ovarian follicles in experimental female reproductive models.
Spermatogenesis & Testicular Function
Studying the impact of combined gonadotropin signaling on the Sertoli and Leydig cells to research the promotion of sperm production and testosterone biosynthesis.
HPG Axis Feedback & Dysregulation
Exploring the influence of exogenous gonadotropins on the systemic feedback loops involving GnRH, providing a model for researching hormonal equilibrium.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | HMG (Human Menopausal Gonadotropin) |
| Components | FSH (Follicle-Stimulating Hormone) + LH (Luteinizing Hormone) |
| Activity Ratio | 1:1 (FSH 75iu : LH 75iu) |
| Purity | Highly Purified / Chromatographic Grade |
| Physical Appearance | Fine, White & Flat Lyophilized Cake |
| Concentration | 75iu per vial |
| Solubility | Highly Soluble in Sterile Water / 0.9% Normal Saline |
| Batch Control | Biological Assay & Purity Verified |
Key Features & Quality Assurance
Advanced Lyophilization Stability
Our proprietary vacuum-sealing process ensures the HMG powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the biological activity of the glycoproteins during long-term storage.
Consistent Biological Potency
Every batch is calibrated using standardized bioassays to ensure that the 75iu dosage provides reproducible physiological responses in specialized experimental designs, free from unexpected potency fluctuations.
Reconstitution & Storage
Reconstitution Guide
-
Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the HMG cake is at the base.
-
Solvent: Reconstitute with Sterile Water or 0.9% Normal Saline.
-
Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
-
Long-term: Store at -20°C (Maintains biological activity for up to 24 months).
-
Short-term: Stable at 2–8°C for up to 3 months.
-
Post-Reconstitution: Store at 2–8°C and utilize within 5-7 days for optimal stability.
Shipping & Documentation
-
Global Logistics: Shipped in discreet, temperature-controlled packaging to protect the sensitive glycoprotein structure of HMG.
-
Verified Quality: A batch-specific COA and potency reports are available for every order.
-
Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This HMG (Human Menopausal Gonadotropin) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
- Comprehensive pharmacological and clinical information for HMG (Human Menopausal Gonadotropin, Menotropins), including therapeutic indications and hormone composition (FSH/LH), can be accessed via DailyMed.
- Curated hormone classification, mechanism of action, and gonadotropin-related biochemical data for HMG are available through DrugBank.
🔍 Deep Dive Research
-
[Technical Guide]: How to Reconstitute and Handle Sensitive Glycoproteins for Research
-
[Hormonal Study]: The Dual Signal: Exploring HMG in Modern Reproductive Neuroendocrinology
Reviews
There are no reviews yet.