Description

Dermorphin

Dermorphin is a high-purity synthetic hepta-peptide originally discovered in the skin of South American frogs (Phyllomedusa genus). In the landscape of advanced neuroscience and molecular pharmacology, Dermorphin is distinguished by its extraordinary potency and high selectivity for the $mu$-opioid receptor (MOR). Structurally unique due to the presence of a D-alanine residue in its second position—a rare natural occurrence of a D-amino acid in vertebrates—Dermorphin is significantly more potent than endogenous enkephalins and morphine. It provides researchers with a high-precision experimental model to investigate the mechanisms of antinociception (pain modulation), receptor internalisation, and the neurobiological pathways of the central and peripheral nervous systems.

Our Dermorphin is synthesized in an ISO 9001:2015 certified environment utilizing high-precision Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from truncated sequences and residual chemical catalysts, guaranteeing the consistency and structural fidelity required for high-stakes studies into opioid signaling and neuro-modulation.

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Research Applications & Mechanisms

$mu$-Opioid Receptor (MOR) Selectivity

Investigating the binding affinity and functional activation of mu-receptors to study the molecular signaling of opioid-induced responses.

Antinociception & Pain Pathway Modulation

Researching the mechanisms through which Dermorphin attenuates pain signals in experimental models of acute and chronic pain.

D-Amino Acid Stability Research

Studying the role of D-Alanine in protecting the peptide from proteolytic degradation, providing a model for researching enhanced peptide bioavailability.

Neuro-Endocrine & Gastrointestinal Interaction

Exploring the influence of Dermorphin on intestinal motility and systemic hormonal release in specialized physiological research designs.

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H2: Technical Specifications

Parameter	Laboratory Standard
Compound	Dermorphin
Sequence	Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	802.9 Da
Concentration	Available in 2mg / 10mg vials
Solubility	Highly Soluble in Water (Aqueous) / PBS
Batch Control	MS & HPLC Analysis Verified

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Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the Dermorphin powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the hepta-peptide during storage.

High-Fidelity Sequence Integrity

Every batch undergoes strict Mass Spectrometry (MS) to confirm the specific D-Ala configuration, ensuring maximal receptor binding affinity and reproducible results in complex neuro-signaling assays.

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Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Dermorphin cake is at the base.

• Solvent: Reconstitute with Sterile Water or PBS.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days for optimal results.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Dermorphin peptide.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This Dermorphin is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

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Scientific Resources & References

• National Center for Biotechnology Information (NCBI): Dermorphin Compound Summary & Bioactivity

• ScienceDirect (Elsevier): Dermorphin blocks apneic response to intravenous bolus injection of fentanyl

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🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [Neurobiology Study]: The D-Alanine Advantage: Exploring Dermorphin in Modern Receptor Research