Description

GHK-Cu (Copper Peptide)

GHK-Cu is a naturally occurring copper complex of the tri-peptide glycyl-L-histidyl-L-lysine. Since its discovery, GHK-Cu has been a focal point in regenerative medicine due to its unique ability to modulate the expression of a vast number of human genes, particularly those involved in collagen synthesis, angiogenesis, and anti-inflammatory responses. In laboratory settings, GHK-Cu is researched for its capacity to promote the activation of fibroblasts and the production of glycosaminoglycans, making it an essential tool for studying dermal remodeling, wound healing acceleration, and cellular senescence reversal.

Our GHK-Cu is synthesized in an ISO 9001:2015 certified environment using high-precision synthesis and controlled chelation with copper ions to ensure a stable, high-affinity complex. We achieve a chemical purity of ≥99%, verified by HPLC and MS. The resulting product is characterized by its distinct deep blue color and superior stability, providing the reliability required for high-resolution studies into extracellular matrix (ECM) stability and stem cell proliferation.

---

Research Applications & Mechanisms

Collagen & Elastin Stimulation

Investigating the upregulation of Type I and III collagen and its impact on the structural integrity of experimental skin models.

Angiogenesis & Vascular Support

Researching the peptide’s role in promoting microvascular growth and improving nutrient delivery in ischemic tissue research.

Anti-Inflammatory & Antioxidant Signaling

Studying the mechanisms through which GHK-Cu reduces pro-inflammatory cytokines (such as IL-6) and increases the activity of antioxidant enzymes like Superoxide Dismutase (SOD).

Hair Follicle & Follicular Growth

Exploring the influence of copper peptides on follicle enlargement and the stimulation of dermal papilla cells in hair growth modeling.

---

Technical Specifications

Parameter	Laboratory Standard
Compound	GHK-Cu (Copper Tri-peptide-1)
Sequence	Gly-His-Lys (Complexed with Cu2+)
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Deep Blue, Smooth & Flat Lyophilized Cake
Molecular Weight	402.9 g/mol (GHK-Cu)
Concentration	Available in 50mg / 100mg vials
Solubility	Highly Soluble in Water (Aqueous) / Bacteriostatic Water
Batch Control	MS & HPLC Analysis Verified

---

Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the GHK-Cu powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the chemical stability of the copper-peptide bond during storage.

Optimal Chelation Stability

Our synthesis process guarantees that the copper ions are perfectly chelated within the GHK sequence, preventing premature dissociation and ensuring consistent bioactivity in experimental assays.

---

Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the GHK-Cu cake is at the base.

• Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution becomes a clear, transparent blue.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 14 days for optimal results.

---

Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the GHK-Cu complex.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

---

⚠️ Research Disclaimer

Product-Specific Safety Notice: This GHK-Cu is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

---

Scientific Resources & References

• National Center for Biotechnology Information (NCBI): GHK-Cu Peptide Summary & Research

• ScienceDirect (Elsevier): Glycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu) Attenuates CuSO4 or LPS induced-inflammation in Zebrafish larvae model

---

🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [Regeneration Study]: The Copper Connection: Exploring GHK-Cu in Modern Tissue Repair Research