Description

Kisspeptin-10

Kisspeptin-10, a decapeptide derived from the KISS1 gene product, is the most potent truncated form of kisspeptin that retains full biological activity. In the landscape of advanced neuroendocrinology, Kisspeptin-10 is recognized as the primary upstream regulator of the reproductive axis. It functions as an essential agonist for the GPR54 (Kiss1R) receptor, directly stimulating the secretion of Gonadotropin-Releasing Hormone (GnRH) from hypothalamic neurons. This provides researchers with a critical experimental model to investigate the initiation of puberty, the regulation of the hypothalamic-pituitary-gonadal (HPG) axis, and the molecular pathways of reproductive dysfunction and hormonal feedback loops.

Our Kisspeptin-10 is synthesized in an ISO 9001:2015 certified environment utilizing high-precision Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from truncated sequences and residual chemical reagents, guaranteeing the consistency and structural fidelity required for high-fidelity endocrine assays and neurobiological research.

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Research Applications & Mechanisms

GnRH Pulse Generation & Regulation

Investigating the direct stimulatory effect of Kisspeptin-10 on GnRH neurons to study the control of LH and FSH secretion levels.

Puberty Initiation & Developmental Research

Researching the triggers of the HPG axis to investigate the molecular mechanisms of precocious or delayed puberty in experimental models.

Metabolic & Reproductive Interplay

Studying how energy balance and metabolic signals (such as leptin) influence kisspeptin expression and its subsequent impact on reproductive viability.

Metastasis Suppression & Oncology Research

Exploring the role of KISS1 signaling in suppressing the migration and invasion of specialized cancer cell lines in research models.

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Technical Specifications

Parameter	Laboratory Standard
Compound	Kisspeptin-10 (Human)
Sequence	Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	1302.4 g/mol
Concentration	Available in 5mg / 10mg vials
Solubility	Highly Soluble in Water (Aqueous) / Bacteriostatic Water
Batch Control	MS & HPLC Analysis Verified

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Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the Kisspeptin-10 powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the decapeptide during storage.

High-Fidelity Sequence Integrity

Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact 10-amino acid sequence, ensuring maximal receptor binding affinity and reproducible results in endocrine signaling assays.

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Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Kisspeptin-10 cake is at the base.

• Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days for optimal results.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Kisspeptin-10 peptide.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This Kisspeptin-10 is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

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Scientific Resources & References

• National Center for Biotechnology Information (NCBI): Kisspeptin-10 Compound Summary

• ScienceDirect (Elsevier): Kisspeptins, new local modulators of male reproduction: A comparative overview

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🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [Endocrine Study]: The Master Regulator: Exploring Kisspeptin-10 in Modern Reproductive Research