Description

KPV peptide (Lys-Pro-Val)

KPV is a potent, naturally occurring tripeptide consisting of the amino acid sequence Lysine-Proline-Valine. Derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone ($alpha$-MSH), KPV retains the powerful anti-inflammatory properties of its parent molecule without inducing melanogenesis (pigmentation). In the field of advanced molecular immunology, KPV is recognized for its ability to translocate into the cell nucleus and modulate inflammatory signaling pathways, particularly by inhibiting NF-$kappa$B (Nuclear Factor kappa-light-chain-enhancer of activated B cells). This provides researchers with a precise experimental tool to investigate the mitigation of cytokine storms, the restoration of intestinal barrier integrity, and the regulation of inflammatory responses in dermatological research models.

Our KPV is synthesized in an ISO 9001:2015 certified environment utilizing high-resolution Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from truncated sequences and residual chemical reagents, guaranteeing the consistency required for sensitive assays involving intestinal epithelial cells and systemic inflammatory biomarkers.

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Research Applications & Mechanisms

NF-$kappa$B Pathway Modulation

Investigating the peptide’s ability to inhibit pro-inflammatory transcription factors to study the reduction of IL-6, IL-8, and TNF-$alpha$ levels.

Intestinal Barrier & Microbiome Research

Researching the role of KPV in promoting mucosal healing and maintaining the structural integrity of the gut lining in experimental models of inflammatory bowel conditions.

Antimicrobial & Antifungal Properties

Studying the mechanisms through which KPV exerts inhibitory effects on pathogens, particularly Staphylococcus aureus and Candida albicans, in host-defense research.

Dermatological Inflammatory Modeling

Exploring the influence of KPV on skin-resident immune cells to research treatments for experimental dermatitis and hyper-inflammatory skin responses.

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Technical Specifications

Parameter	Laboratory Standard
Compound	KPV (Lys-Pro-Val)
Sequence	Lys-Pro-Val
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	341.4 g/mol
Concentration	Available in 5mg / 10mg vials
Solubility	Highly Soluble in Water (Aqueous) / Bacteriostatic Water
Batch Control	MS & HPLC Analysis Verified

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Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the KPV powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and protects the tripeptide from oxidative degradation during long-term storage.

High-Fidelity Sequence Integrity

Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact Lys-Pro-Val sequence, ensuring maximal receptor interaction and reproducible data in cellular research.

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Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the KPV cake is at the base.

• Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days for optimal results.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the KPV peptide.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This KPV is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

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Scientific Resources & References

• National Center for Biotechnology Information (NCBI): Compound Summary – KPV (Lys-Pro-Val; α-MSH-derived tripeptide)

• PubMed – NIH: Research on KPV (α-MSH fragment) in anti-inflammatory and immunomodulatory pathways

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🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [Immunity Study]: Beyond the Surface: The Role of KPV in Modern Anti-Inflammatory Research