Description

Melanotan I (MT1)

Melanotan I (MT1), also known as Afamelanotide, is a high-purity synthetic peptide analog of the endogenous alpha-melanocyte-stimulating hormone ($alpha$-MSH). Composed of 13 amino acids, MT1 is a non-selective agonist of the Melanocortin receptors (primarily MC1R). In the field of photobiology and dermatological research, MT1 is distinguished by its ability to stimulate eumelanin production—the photoprotective pigment—independently of UV radiation exposure. This provides researchers with a sophisticated experimental model to investigate systemic photoprotection, the mechanisms of DNA repair in skin cells, and the mitigation of phototoxicity in research models of erythropoietic protoporphyria (EPP).

Our Melanotan I is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing advanced Solid-Phase Peptide Synthesis (SPPS) and high-resolution HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated sequences and residual synthesis reagents, guaranteeing the consistency and structural fidelity required for high-stakes studies into melanocortin signaling and pigmentary homeostasis.

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Research Applications & Mechanisms

Eumelanin Synthesis & Pigmentation

Investigating the stimulation of the MC1R pathway on melanocytes to study the non-UV dependent production of photoprotective pigments.

Photoprotection & UV-Induced DNA Damage

Researching the potential of MT1 to reduce the formation of cyclobutane pyrimidine dimers (CPDs) and its role in protecting skin tissue from oxidative stress.

MC1R Signaling & Cellular Response

Studying the intracellular signaling cascades, including the cAMP pathway, triggered by MT1 to observe its effects on cellular proliferation and differentiation.

Experimental Photomedicine Models

Exploring the efficacy of MT1 in mitigating phototoxic reactions and inflammatory responses in specialized dermatological research designs.

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Technical Specifications

Parameter	Laboratory Standard
Compound	Melanotan I (MT1 / Afamelanotide)
Sequence	Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	1646.8 Da
Concentration	10mg per vial
Solubility	Highly Soluble in Water (Aqueous) / Bacteriostatic Water
Batch Control	MS & HPLC Analysis Verified

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Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the Melanotan I powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and protects the sensitive peptide sequence from oxidative degradation during long-term storage.

Structural Fidelity & Stability

Every batch undergoes strict Mass Spectrometry (MS) to confirm the 13-amino acid sequence, ensuring maximal receptor binding affinity and reproducible results in laboratory assays.

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Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the MT1 cake is at the base.

• Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 14-21 days for optimal results.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Melanotan I peptide.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This Melanotan I (MT1) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

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Scientific Resources & References

• National Center for Biotechnology Information (NCBI): Melanotan I Compound Summary (CID 16132313)

• Partitioning properties and degradation kinetics of the [Nle4-DPhe7]α-MSH analog Melanotan-I (MT-I)

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🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [Photobiology Study]: Protecting the Genome: The Role of Melanotan I in Modern Skin Research