Description

MOTS-c (Human)

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a potent, naturally occurring 16-amino acid signaling peptide encoded by the mitochondrial genome. In the field of advanced metabolic research and geroscience, MOTS-c is highly distinguished for its role as a “mitochondrial hormone” that coordinates communications between mitochondria and the nucleus. Its primary mechanism involves the activation of the AMPK (AMP-activated protein kinase) pathway and the promotion of AICAR levels, which collectively enhance glucose uptake and fatty acid oxidation. It provides researchers with a robust experimental tool to investigate metabolic flexibility, insulin sensitivity, and cellular longevity signaling across various tissue models.

Our MOTS-c is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing state-of-the-art solid-phase synthesis and high-resolution multi-stage HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated isomers and residual synthesis catalysts, guaranteeing the consistency required for high-stakes research into mitochondrial-nuclear communication and cellular energetics.

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Research Applications & Mechanisms

AMPK Pathway & Glucose Metabolism

Investigating the peptide’s ability to activate AMPK signaling to study non-insulin-dependent glucose uptake in skeletal muscle models.

Mitochondrial-Nuclear Signaling

Researching how MOTS-c translocates to the nucleus under metabolic stress to regulate gene expression and cellular adaptation.

Lipid Oxidation & Thermogenesis

Studying the pathways through which MOTS-c influences fatty acid metabolism and its potential role in investigating metabolic dysfunction-associated syndromes.

Exercise Mimetic & Longevity Research

Exploring the role of mitochondrial-derived peptides in simulating the metabolic benefits of physical activity and their impact on age-related physiological decline.

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Technical Specifications

Parameter	Laboratory Standard
Compound	MOTS-c (Human)
Sequence	Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Ala-Leu-Ser-Lys-Leu-Leu
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	2174.6 Da
Concentration	10mg / 15mg / 20mg / 40mg per vial
Bulk Availability	Wholesale / Bulk Orders Supported
Batch Control	MS & HPLC Analysis Verified

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Key Features & Quality Assurance

Wholesale-Grade Manufacturing

We specialize in large-scale production (bulk wholesale) of MOTS-c, maintaining identical purity and stability standards for single vials and high-volume orders. This ensures that long-term, large-sample-size studies remain consistent across batches.

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the MOTS-c powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid reconstitution and protects the sensitive mitochondrial sequence from oxidative degradation.

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Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the MOTS-c cake is at the base.

• Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the integrity of the MOTS-c molecular structure.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Wholesale Inquiries: For bulk pricing and custom synthesis, please contact our laboratory sales team.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This MOTS-c is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

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Scientific Resources & References

• National Center for Biotechnology Information (NCBI): MOTS-c A promising mitochondrial-derived peptide for therapeutic exploitation.

• ScienceDirect (Elsevier):Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis

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🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [Metabolic Study]: The Mitochondrial Revolution: Exploring MOTS-c in Modern Bioenergetics Research