Description

Dulaglutide

Dulaglutide is a high-purity, synthetic fusion protein that functions as a potent Glucagon-Like Peptide-1 (GLP-1) receptor agonist. In the field of advanced metabolic research, Dulaglutide is distinguished by its innovative molecular architecture: it consists of two identical chains of a GLP-1 analog, modified to resist DPP-4 degradation, each covalently linked to a modified human immunoglobulin G4 (IgG4) Fc fragment. This fusion significantly increases its molecular size and reduces renal clearance, resulting in a prolonged biological half-life. It provides researchers with a robust experimental model to investigate glucose-dependent insulin secretion, the inhibition of inappropriate glucagon release, and the molecular mechanisms of delayed gastric emptying and appetite suppression.

Our Dulaglutide is produced in an ISO 9001:2015 certified environment utilizing advanced recombinant DNA technology in mammalian cell lines to ensure proper protein folding and glycosylation. We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from bacterial endotoxins and truncated variants, guaranteeing the high-fidelity data necessary for longitudinal studies into metabolic homeostasis and weight regulation pathways.

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Research Applications & Mechanisms

Glycemic Control & Insulin Signaling

Investigating the potentiation of glucose-dependent insulin secretion from pancreatic beta-cells in research models of metabolic dysfunction.

Satiety Mechanisms & Gastric Emptying

Researching the influence of GLP-1R activation on central nervous system satiety centers and its role in investigating delayed gastrointestinal motility.

Adipose Tissue & Weight Regulation

Studying the mechanisms through which long-acting GLP-1 analogs promote weight loss and influence lipid metabolism in experimental obesity studies.

Cardioprotective & Endothelial Research

Exploring the potential non-glycemic effects of Dulaglutide on cardiovascular stability and vascular endothelial health in systemic research designs.

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Technical Specifications

Parameter	Laboratory Standard
Compound	Dulaglutide
Structure	GLP-1-IgG4-Fc Fusion Protein
Purity (HPLC)	≥99% (Pharmaceutical Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Weight	~59.7 kDa
Concentrations	Available in 5mg / 10mg vials
Solubility	Highly Soluble in Water (Aqueous) / Sterile Saline
Batch Control	HPLC, MS & Endotoxin Analysis Verified

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Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the Dulaglutide powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure protects the large fusion protein during storage and ensures rapid, clear reconstitution.

Enhanced Half-Life Stability

The IgG4-Fc fusion design ensures that the peptide remains active in experimental models for extended periods, allowing for research into long-term metabolic adaptations without frequent dosing.

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Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Dulaglutide cake is at the base.

• Solvent: Reconstitute with Sterile Water or 0.9% Normal Saline.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl very gently until the solution is clear. Large fusion proteins are sensitive to mechanical agitation.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 14 days for optimal results.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Dulaglutide protein.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This Dulaglutide is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

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Scientific Resources & References

• Comprehensive chemical, pharmacological, and structural data for Dulaglutide can be accessed via PubChem .
• Regulatory and clinical labeling information for Dulaglutide, including approved indications and pharmacological classification, is available through DailyMed

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🔍 Deep Dive Research

• [Technical Guide]: Handling Large Fusion Proteins: Best Practices for Dulaglutide Stability

• [Metabolic Study]: The Extended Curve: Exploring Dulaglutide in Modern Obesity Research