Description

NAD+ (Nicotinamide Adenine Dinucleotide)

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in all living cells, serving as a fundamental electron carrier in redox reactions. In the landscape of advanced geroscience and metabolic research, NAD+ is a primary focus due to its role as a necessary substrate for enzymes involved in cellular maintenance, including Sirtuins (SIRT1-7) and PARPs (Poly ADP-Ribose Polymerases). It provides researchers with a vital tool to investigate the mechanisms of mitochondrial bioenergetics, the regulation of oxidative stress, and the molecular pathways of DNA damage repair. As cellular NAD+ levels naturally decline with age, this compound is central to studies targeting cellular rejuvenation and the prevention of metabolic dysfunction.

Our NAD+ is manufactured in an ISO 9001:2015 certified environment using high-precision enzymatic synthesis and purification processes. We guarantee a chemical purity of ≥98%, ensuring the compound is free from heavy metals and residual solvents. This high standard provides the reliability and reproducibility required for sensitive enzymatic assays, mitochondrial respiration studies, and longitudinal research into longevity signaling.

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Research Applications & Mechanisms

Mitochondrial Bioenergetics & ATP Production

Investigating the role of the NAD+/NADH ratio in the electron transport chain and its influence on oxidative phosphorylation efficiency.

Sirtuin Activation & Epigenetic Regulation

Researching how NAD+ availability modulates Sirtuin activity, focusing on its impact on gene expression, protein deacetylation, and cellular lifespan.

DNA Repair & Genomic Stability

Studying the activation of PARP enzymes by NAD+ in response to DNA strand breaks and the maintenance of chromosomal integrity in aging models.

Circadian Rhythm & Metabolic Homeostasis

Exploring the interplay between NAD+ levels and the biological clock (NAMPT-mediated cycles) to observe its effects on metabolic synchronization.

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Technical Specifications

Parameter	Laboratory Standard
Compound	NAD+ (Nicotinamide Adenine Dinucleotide)
Form	Lyophilized White Powder (Acid Form / Sodium Salt)
Purity (HPLC)	≥98% (Research Grade)
Physical Appearance	Fine, Smooth & Flat Lyophilized Cake
Molecular Formula	C21H27N7O14P2
Molecular Weight	663.4 g/mol
Concentration	Available in 100mg / 500mg / 1000mg vials
Solubility	Highly Soluble in Water (Aqueous) / Sterile Saline
Batch Control	Certificate of Analysis (COA) Verified

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Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the NAD+ powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the chemical stability of the nucleotide during storage.

High-Fidelity Redox Potential

Every batch is tested to ensure maximum enzymatic activity and redox stability, providing consistent results in both in-vitro metabolic assays and systemic experimental designs.

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Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the NAD+ cake is at the base.

• Solvent: Reconstitute with Sterile Water or 0.9% Normal Saline.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains stability for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 7-10 days. NAD+ is sensitive to light and temperature once in solution; keep in dark containers.

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Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the stability of the NAD+ molecule.

• Verified Quality: A batch-specific COA is available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

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⚠️ Research Disclaimer

Product-Specific Safety Notice: This NAD+ is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

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Scientific Resources & References

• National Center for Biotechnology Information (NCBI): NAD+ Compound Summary (CID 5893)

• ScienceDirect (Elsevier): Peer-reviewed Research on NAD+ Metabolism and Cellular Aging

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🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Metabolic Coenzymes for Maximum Stability

• [Longevity Study]: The NAD+ Revolution: Exploring Sirtuin Activation in Modern Bioenergetics Research